Nonmonotonic variation with salt concentration of the second virial coefficient in protein solutions

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Nonmonotonic variation with salt concentration of the second virial coefficient in protein solutions.

The osmotic virial coefficient B2 of globular protein solutions is calculated as a function of added salt concentration at fixed pH by computer simulations of the "primitive model." The salt and counterions as well as a discrete charge pattern on the protein surface are explicitly incorporated. For parameters roughly corresponding to lysozyme, we find that B2 first decreases with added salt con...

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ژورنال

عنوان ژورنال: Physical Review E

سال: 2003

ISSN: 1063-651X,1095-3787

DOI: 10.1103/physreve.67.051404